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Hierarchical modeling of force generation in cardiac muscle

Abstract : Performing physiologically relevant simulations of the beating heart in clinical context requires to develop detailed models of the microscale force generation process. These models however may reveal difficult to implement in practice due to their high computational costs and complex calibration. We propose a hierarchy of three interconnected muscle contraction models-from the more refined to the more simplified-that are rigorously and systematically related with each other, offering a way to select, for a specific application, the model that yields a good trade-off between physiological fidelity, computational cost and calibration complexity. The three models families are compared to the same set of experimental data to systematically assess what physiological indicators can be reproduced or not and how these indicators constrain the model parameters. Finally, we discuss the applicability of these models for heart simulation.
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Submitted on : Tuesday, May 12, 2020 - 12:59:16 PM
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François Kimmig, Matthieu Caruel. Hierarchical modeling of force generation in cardiac muscle. Biomechanics and Modeling in Mechanobiology, Springer Verlag, 2020, 19, pp.2567-2601. ⟨10.1007/s10237-020-01357-w⟩. ⟨hal-02570784⟩

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