Impact of the Timing of Antibiotic Administration on Digestive Colonization with Carbapenemase-Producing Enterobacteriaceae in a Murine Model

Rémi Le Guern (1) , Teddy Grandjean (1) , Marvin Bauduin (1) , Martin Figeac (2) , Guillaume Millot (3) , Aurore Loquet (3) , Karine Faure (1) , Eric Kipnis (1) , Rodrigue Dessein (1)

1 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
2 Plateforme de génomique fonctionnelle et structurelle [Lille]
3 CHRU Lille - Centre Hospitalier Régional Universitaire [CHU Lille]

While antibiotic use is a risk factor of carbapenemase-producing Enterobacteriaceae (CPE) acquisition, the importance of timing of antibiotic administration relative to CPE exposure remains unclear. In a murine model of gut colonization by New Delhi metallo-beta-lactamase-1 (NDM-1)-producing Klebsiella pneumoniae, a single injection of clindamycin within at most 1 week before or after CPE exposure induced colonization persisting up to 100 days. The timing of antibiotic administration relative to CPE exposure may be relevant to infection control and antimicrobial stewardship approaches.

Domaines: Maladies infectieuses; Pharmacologie

Rémi Le Guern, Teddy Grandjean, Marvin Bauduin, Martin Figeac, Guillaume Millot, et al.. Impact of the Timing of Antibiotic Administration on Digestive Colonization with Carbapenemase-Producing Enterobacteriaceae in a Murine Model. Antimicrobial Agents and Chemotherapy, 2019, 63 (6), pp.e00360-19. ⟨10.1128/AAC.00360-19⟩. ⟨hal-02566181⟩