Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

Shannon Takala-Harrison (1) , Christopher Jacob , Cesar Arze (1) , Michael Cummings , Joana Silva , Arjen M Dondorp (2) , Mark M Fukuda (3) , Tran Tinh Hien (4) , Mayfong Mayxay (5) , Harald Noedl (6) , François Nosten (7) , Myat Kyaw , Nguyen Thanh Thuy Nhien , Mallika Imwong (8) , Delia Bethell , Youry Se , Chanthap Lon (9) , Stuart Tyner , David Saunders (9) , Frédéric Ariey (10) , Odile Mercereau-Puijalon (10) , Didier Ménard (11) , Paul Newton (5) , Maniphone Khanthavong (12) , Bouasy Hongvanthong (12) , Peter Starzengruber , Hans-Peter Fuehrer (13) , Paul Swoboda (14) , Wasif Khan , Aung Pyae Phyo , Myaing Nyunt , Myat Nyunt , Tyler Brown , Matthew Adams , Christopher Pepin , Jason Bailey , John Tan , Michael T Ferdig (15) , Taane Clark (16) , Olivo Miotto (2) , Bronwyn Macinnis (17) , Dominic P. Kwiatkowski (18) , Nicholas J White (2) , Pascal Ringwald (19) , Christopher V Plowe (1)

1 University of Maryland School of Medicine
2 Mahidol Oxford Tropical Medicine Research Unit
3 U.S. President's Malaria Initiative [Bangkok, Thaïlande]
4 OUCRU - Oxford University Clinical Research Unit [Ho Chi Minh City]
5 LOMWRU - Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit
6 Institute of Specific Prophylaxis and Tropical Medicine
7 SMRU - Shoklo Malaria Research Unit [Mae Sot, Thailand]
8 Department of Molecular Tropical Medicine and Genetics [Bangkok, Thaïlande]
9 AFRIMS - Armed Forces Research Institute of Medical Sciences [Bangkok]
10 Immunologie moléculaire des parasites
11 Institut Pasteur du Cambodge
12 National Center for Malariology, Parasitology and Entomology
13 Institute of Parasitology [Vienna]
14 INFO - Département informatique
15 Eck Institute for Global Health
16 Faculty of Infectious and Tropical Diseases
17 The Wellcome Trust Sanger Institute [Cambridge]
18 The Wellcome Trust Centre for Human Genetics [Oxford]
19 OMS / WHO - Organisation Mondiale de la Santé / World Health Organization Office

The emergence of artemisinin-resistant Plasmodium falciparum in Southeast Asia threatens malaria treatment efficacy. Mutations in a kelch protein encoded on P. falciparum chromosome 13 (K13) have been associated with resistance in vitro and in field samples from Cambodia.

Mots clés: Plasmodium falciparum; Southeast Asia; artemisinin resistance; kelch; malaria

Domaines: Maladies infectieuses

Shannon Takala-Harrison, Christopher Jacob, Cesar Arze, Michael Cummings, Joana Silva, et al.. Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia. Journal of Infectious Diseases, 2015, 211 (5), pp.670-679. ⟨10.1093/infdis/jiu491⟩. ⟨hal-02560668⟩