Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic properties

Fabien Accadbled (1) , Bernard Tinant , Eric Hénon (1) , Danièle Carrez (2) , Alain Croisy (2) , Sandrine Bouquillon (1)

1 ICMR - Institut de Chimie Moléculaire de Reims - UMR 7312
2 INSERM U759

Original palladium complexes involving (-)-ephedrine, (-)-norephedrine, L-prolinol, L-valinol and L-isoleucinol have been rapidly prepared in neutral or basic medium and simply purified. They have been fully characterized by classical analytical methods and four of them were characterized by X-Ray analysis. In parallel with the experimental work, HF-DFT(B3LYP/PCM) computations were performed to obtain additional structural information. Their antiproliferative properties have been evaluated and some complexes showed small activities especially towards HT29 human cancer cells.

Domaines: Chimie

Fabien Accadbled, Bernard Tinant, Eric Hénon, Danièle Carrez, Alain Croisy, et al.. Synthesis of chiral β-aminoalcohol palladium complexes exhibiting cytotoxic properties. Dalton Transactions, 2010, 39 (38), pp.8982. ⟨10.1039/c0dt00328j⟩. ⟨hal-02540474⟩