Evidence on the direct correlation between miR‐31 and IL‐22 axis in IMQ‐induced psoriasis

Florence Abdallah (1) , Chantal Pichon (1)

1 CBM - Centre de biophysique moléculaire

Psoriatic skin is characterized by a deregulated profile of miRNAs that are contributing in disease development. In this study, we focus on miR-31, one of the upregulated miRNAs known to promote keratinocytes proliferation and migration. Moreover, miR-31 expression induction was dependent on a large panel of cytokines including IL-22. Here, we aimed at investigating the relationship between miR-31-5p and IL-22 axis; and by searching novel molecular target for miR-31-5p in keratinocytes. Our data identify a direct correlation between miR-31-5p and IL-22 in psoriasis with Pwp1 as new potential target. These findings confirm the important role of miR-31 in psoriasis onset and provide a basis for further investigations in miRNAs field in context of skin diseases.

Domaines: Chimie

Florence Abdallah, Chantal Pichon. Evidence on the direct correlation between miR‐31 and IL‐22 axis in IMQ‐induced psoriasis. Experimental Dermatology, 2019, 28 (11), pp.1336-1340. ⟨10.1111/exd.14001⟩. ⟨hal-02521769⟩