Naftazone accelerates human saphenous vein endothelial cell proliferation in vitro.

C Klein-Soyer , C Bloy , Gisele Haan-Archipoff (1) , Alain Beretz (2) , Jean-Pierre Cazenave (3)

1 IBMP - Institut de Biologie Moléculaire des Plantes
2 Université Louis Pasteur - Strasbourg I
3 LABM - Laboratoire d'Analyses de Biologie Médicale

Restoration of a haemocompatible surface after endothelial damage induced by treatments such as embolectomy, angioplasty, endarterectomy or irradiation or following vascular graft implantation is an important factor for the ultimate success of these interventions. The development of substances which enhance endothelial cell growth and accelerate their proliferation is therefore of great interest in such situations. In the present work naftazone was shown to accelerate human saphenous vein endothelial cell proliferation in vitro at concentrations which did not alter the hemostatic balance, resulting in a cell density at confluence 20% higher than in controls. This compound was able to partially substitute for serum requirements and further displayed additive effects in the presence of fibroblast growth factors. Thus naftazone, an original synthetic molecule distinct from growth factor peptides, is a promising candidate drug for the amelioration of vascular repair.

Mots clés: Cell Division/drug effects Cell Membrane/drug effects Cells; Cultured Endothelium; Vascular/cytology/*drug effects Fibroblast Growth Factor 1/pharmacology Fibroblast Growth Factor 2/pharmacology Heparin/pharmacology Humans Kinetics Naphthoquinones/*pharmacology Saphenous Vein/cytology/*drug effects Thrombomodulin/drug effects Thromboplastin/drug effects

Domaines: Sciences pharmaceutiques

C Klein-Soyer, C Bloy, Gisele Haan-Archipoff, Alain Beretz, Jean-Pierre Cazenave. Naftazone accelerates human saphenous vein endothelial cell proliferation in vitro.. Nouvelle revue francaise d'hematologie, 1995, 37 (3), pp.187-192. ⟨hal-02518117⟩