Skip to Main content Skip to Navigation
Journal articles

Thermosensitive PNIPAM grafted alginate/chitosan PEC

Abstract : Smart biomaterial functionality such as controlled adhesion properties is crucial to limit strip-off injuries. Among functional polymers, poly-N(isopropylacrylamide) (PNIPAM) allows surface properties to be changed depending on the temperature, with a transition of its properties that occurs around 32 °C, called the lower critical solution temperature (LCST). This transition is expected to modify surface interactions. Alginate and chitosan are biocompatible polymers commonly combined as polyelectrolyte complex (PEC) and are suitable for wound dressing applications. As a complex system, however, it is not so trivial to achieve an efficient functionalization. Herein, we elaborated a procedure to functionalize the surface of alginate/chitosan PECs without altering their intrinsic properties. FTIR revealed that acidic treatment led to a partial decomplexation of the PECs. Therefore, while the N-Hydroxysuccinimide/N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide (NHS/EDC) coupling usually requires an intermediate pH, we showed that a preliminary acidification seemed to increase the surface grafting efficiency. Water contact angle increased from 51° to 72°, showing that PNIPAM enhanced the surface hydrophobicity. The LCST transition modified the interaction forces between PNIPAM and model surfaces: it revealed an unexpected thermosensitive behaviour as hydrophobic transition favoured interactions with hydrophilic surfaces. It was presumably due to PNIPAM/PEC substrate interactions. Finally, the surface modification did not affect the release properties of the PEC biomaterial.
Complete list of metadata

Cited literature [33 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-02498201
Contributor : Open Archive Toulouse Archive Ouverte (OATAO) Connect in order to contact the contributor
Submitted on : Wednesday, March 4, 2020 - 11:30:12 AM
Last modification on : Tuesday, September 27, 2022 - 4:39:18 AM
Long-term archiving on: : Friday, June 5, 2020 - 1:46:26 PM

File

Conzatti_25566.pdf
Files produced by the author(s)

Identifiers

Citation

Guillaume Conzatti, Farouk Ayadi, Sandrine Cavalie, Nicolas Carrere, Audrey Tourrette. Thermosensitive PNIPAM grafted alginate/chitosan PEC. Applied Surface Science, Elsevier, 2019, 467-468, pp.940-948. ⟨10.1016/j.apsusc.2018.10.269⟩. ⟨hal-02498201⟩

Share

Metrics

Record views

20

Files downloads

83