Sensitive liposomes encoded with oligonucleotide amphiphiles: a biocompatible switch

Arnaud Gissot (1) , Carmelo Di Primo (1) , Isabelle Bestel (2) , Gregory Giannone (3) , Hubert Chapuis (4) , Philippe Barthélémy (1)

1 ARNA - Acides Nucléiques : Régulations Naturelle et Artificielle
2 INSERM U869, Institut Européen de Chimie Biologie
3 IINS - Interdisciplinary Institute for Neuroscience [Bordeaux]
4 ARNA - Régulations Naturelles et Artificielles

DNA-tagged liposomes made of DOPC specifically bind to a fluorescently labelled complementary ss-DNA with virtually no influence from the lipid bilayer despite the absence of a linker; depending on an external stimulus, either physical (temperature) or chemical (competitive complementary ON sequences), the liposomes switch between an on and off fluorescent state depending on the location of the probe either at the surface or in the bulk.

Domaines: Chimie organique; Sciences du Vivant [q-bio]; Biophysique

Arnaud Gissot, Carmelo Di Primo, Isabelle Bestel, Gregory Giannone, Hubert Chapuis, et al.. Sensitive liposomes encoded with oligonucleotide amphiphiles: a biocompatible switch. Chemical Communications, 2008, 43, pp.5550-5552. ⟨10.1039/B812398E⟩. ⟨hal-02484276⟩