Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences

Brune Vialet (1) , Arnaud Gissot (1) , Romain Delzor (1) , Philippe Barthélémy (1)

1 ARNA - Acides Nucléiques : Régulations Naturelle et Artificielle

G-quadruplexes (G4) represent attractive supramolecular scaffolds. In this communication, we show that the lipid modification of a G4 prone oligonucleotide sequence drastically increases the probability of forming tetramolecular parallel G4s with unprecedented conformational control over other unspecific oligomers or folds.

Domaines: Chimie organique; Sciences du Vivant [q-bio]; Biophysique

Brune Vialet, Arnaud Gissot, Romain Delzor, Philippe Barthélémy. Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences. Chemical Communications, 2017, 53 (84), pp.11560-11563. ⟨10.1039/C7CC05693A⟩. ⟨hal-02475462⟩