Artemisinin-Derivative-NHC-gold(I)-Hybrid with enhanced cytotoxic activity through inhibiting NRF2 transcriptional activity

Chen Zhang (1) , Pierre-Yves Fortin (2) , Guillaume Barnoin (1) , Xue Qin (1) , Xing Wang (1) , Alvaro Fernandez Alvarez (1) , Christian Bijani (1) , Marie-Lise Maddelein (2) , Catherine Hemmert (1) , Olivier Cuvillier (2) , Heinz Gornitzka (1)

1 LCC - Laboratoire de chimie de coordination
2 IPBS - Institut de pharmacologie et de biologie structurale

Mots clés: Gold; Artemisinin; Chemoresistance; Cancer; NRF2; HIF; Sorafenib; Hypoxia; Metallodrugs

Domaines: Chimie de coordination; Chimie thérapeutique; Biologie moléculaire; Biochimie [q-bio.BM]; Cancer

Chen Zhang, Pierre-Yves Fortin, Guillaume Barnoin, Xue Qin, Xing Wang, et al.. Artemisinin-Derivative-NHC-gold(I)-Hybrid with enhanced cytotoxic activity through inhibiting NRF2 transcriptional activity. 2020. ⟨hal-02442823v1⟩