The antibody/microbiota interface in health and disease

Delphine Sterlin (1, 2, 3) , Jehane Fadlallah (4, 5, 6) , Emma Slack (7) , Guy Gorochov (1, 2)

1 CIMI - Centre d'Immunologie et des Maladies Infectieuses
2 CHU Pitié-Salpêtrière [AP-HP]
3 Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology
4 UPD7 - Université Paris Diderot - Paris 7
5 Service d'Immunopathologie [Hôpital Saint-Louis, Paris]
6 (EA_3518) - Recherche clinique appliquée à l'hématologie
7 ETH Zürich - Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich]

The human intestine is densely colonized with commensal microbes that stimulate the immune system. While secretory Immunoglobulin (Ig) A is known to play a crucial role in gut microbiota compartmentalization, secretory IgM, and systemic IgG have recently been highlighted in host-microbiota interactions as well. In this review, we discuss important aspects of secretory IgA biology, but rather than focusing on mechanistic aspects of IgA impact on microbiota, we stress the current knowledge of systemic antibody responses to whole gut microbiota, in particular their generation, specificities, and function. We also provide a comprehensive picture of secretory IgM biology. Finally, therapeutic and diagnostic implications of these novel findings for the treatment of various diseases are outlined.

Domaines: Immunologie

Delphine Sterlin, Jehane Fadlallah, Emma Slack, Guy Gorochov. The antibody/microbiota interface in health and disease. Mucosal Immunology, 2020, 13 (1), pp.3-11. ⟨10.1038/s41385-019-0192-y⟩. ⟨hal-02433465⟩