Evaluating the Impact of Variable Phosphorothioate Content in Tricyclo-DNA Antisense Oligonucleotides in a Duchenne Muscular Dystrophy Mouse Model

Lucía Echevarría (1) , Philippine Aupy , Karima Relizani (2) , Thomas Bestetti , Graziella Griffith (1) , Florence Blandel , Marek Komisarski , Adrian Haeberli , Fedor Svinartchouk (3) , Luis Garcia (4) , Aurélie Goyenvalle

1 END-ICAP - Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées
2 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
3 CRATG - Centre de recherche et d'applications sur les thérapies géniques
4 ICMC-USP - Instituto de Ciências Mathemàticas e de Computação [São Carlos]

Domaines: Sciences du Vivant [q-bio]

Lucía Echevarría, Philippine Aupy, Karima Relizani, Thomas Bestetti, Graziella Griffith, et al.. Evaluating the Impact of Variable Phosphorothioate Content in Tricyclo-DNA Antisense Oligonucleotides in a Duchenne Muscular Dystrophy Mouse Model. Nucleic Acid Therapeutics, 2019, 29 (3), pp.148-160. ⟨10.1089/nat.2018.0773⟩. ⟨hal-02407933⟩