Nano-analytical characterization of endogenous minerals in healthy placental tissue: mineral distribution, composition and ultrastructure
A. H. C. Anthis
(1)
,
Elena Tsolaki
(2)
,
Louis Didierlaurent
(1)
,
Samuel Staubli
(1)
,
Robert Zboray
(3)
,
Antonia Neels
(3)
,
Dörthe Dietrich
(4)
,
Pius Manser
(1)
,
Lotus May Desbiolles
(5)
,
Sebastian Leschka
(5)
,
Simon Wildermuth
(5)
,
Sandro Lehner
(6)
,
Pascale Chavatte-Palmer
(7)
,
Wolfram Jochum
(8)
,
Peter Wick
(1)
,
Alex Dommann
(1, 3)
,
Tina Bürki-Turnherr
(1)
,
Tina Fischer
(9)
,
René Hornung
(9)
,
Sergio Bertazzo
(2)
,
Inge K. Herrmann
(1, 10)
1
Laboratory for Particles Biology Interactions, Department Materials Meet Life
2 Department of Medical Physics & Biomedical Engineering
3 Center for X-ray Analytics, Department Materials Meet Life
4 Institute of Inorganic and Analytical Chemistry
5 Division of Radiology and Nuclear Medicine
6 Laboratory for Advanced Fibers and Laboratory for Biointerfaces, Department Materials Meet Life
7 BDR - Biologie du Développement et Reproduction
8 Institute of Pathology
9 Department of Gynaecology
10 Nanoparticle Systems Engineering Laboratory, Institute of Process Engineering (IPE), Department of Mechanical and Process Engineering (D-MAVT)
2 Department of Medical Physics & Biomedical Engineering
3 Center for X-ray Analytics, Department Materials Meet Life
4 Institute of Inorganic and Analytical Chemistry
5 Division of Radiology and Nuclear Medicine
6 Laboratory for Advanced Fibers and Laboratory for Biointerfaces, Department Materials Meet Life
7 BDR - Biologie du Développement et Reproduction
8 Institute of Pathology
9 Department of Gynaecology
10 Nanoparticle Systems Engineering Laboratory, Institute of Process Engineering (IPE), Department of Mechanical and Process Engineering (D-MAVT)
Elena Tsolaki
- Fonction : Auteur
- PersonId : 1060017
Louis Didierlaurent
- Fonction : Auteur
- PersonId : 1060018
Samuel Staubli
- Fonction : Auteur
- PersonId : 1060019
Robert Zboray
- Fonction : Auteur
- PersonId : 1060020
Antonia Neels
- Fonction : Auteur
- PersonId : 1060021
Dörthe Dietrich
- Fonction : Auteur
- PersonId : 1060022
Pius Manser
- Fonction : Auteur
- PersonId : 1060023
Lotus May Desbiolles
- Fonction : Auteur
- PersonId : 1060024
Sandro Lehner
- Fonction : Auteur
- PersonId : 1060027
Pascale Chavatte-Palmer
- Fonction : Auteur
- PersonId : 734858
- IdHAL : pascale-chavatte-palmer
- ORCID : 0000-0002-4581-6092
- IdRef : 153497998
Peter Wick
- Fonction : Auteur
- PersonId : 1060029
Alex Dommann
- Fonction : Auteur
- PersonId : 1060030
Tina Bürki-Turnherr
- Fonction : Auteur
- PersonId : 1060031
Sergio Bertazzo
- Fonction : Auteur
- PersonId : 1060034
Résumé
Despite its crucial role, the placenta is the least understood human organ. Recent clinical studies indicate a direct association between placental calcification and maternal and offspring health. This study reveals distinct characteristics of minerals formed during gestational ageing using cutting-edge nano-analytical characterization and paves the way for investigations focused on the identification of potential markers for disease risks in a clinical setting based on atypical placental mineral fingerprints.