Spatially encoded diffusion-ordered NMR spectroscopy of reaction mixtures in organic solvents

Ghanem Hamdoun (1) , Ludmilla Guduff (1) , Carine van Heijenoort (1) , Christophe Bour (2) , Vincent Gandon (2) , Jean-Nicolas Dumez (1)

1 ICSN - Institut de Chimie des Substances Naturelles
2 ICMMO - Institut de Chimie Moléculaire et des Matériaux d'Orsay

Diffusion-ordered NMR spectroscopy (DOSY) is a powerful method for the analysis of mixtures. Classic DOSY methods require several minutes of acquisition, and we show here that DOSY experiments can be recorded in less than one second for the challenging case of solution mixtures in low-viscosity solvents. The proposed method relies on a spatial encoding of the diffusion dimension, for which convection-compensation and spectral-selection strategies are introduced. The method is illustrated with the analysis of a reaction mixture, for which more accurate estimates of the diffusion coefficents are obtained.

Domaines: Chimie analytique; Autre

Ghanem Hamdoun, Ludmilla Guduff, Carine van Heijenoort, Christophe Bour, Vincent Gandon, et al.. Spatially encoded diffusion-ordered NMR spectroscopy of reaction mixtures in organic solvents. Analyst, 2018, 143 (14), pp.3458-3464. ⟨10.1039/C8AN00434J⟩. ⟨hal-02392883⟩