Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission

Christoph Freyer (1, 2) , Lynsey Cree (3) , Arnaud Mourier (4, 2) , James Stewart (2) , Camilla Koolmeister (1) , Dusanka Milenkovic (5, 2) , Timothy Wai (6) , Vasileios Floros (3) , Erik Hagström (1) , Emmanouella Chatzidaki (1) , Rudolf J Wiesner (7, 8) , David C Samuels (9) , Nils-Göran Larsson (2, 1) , Patrick Chinnery (10, 3)

1 Karolinska University Hospital [Stockholm]
2 Max planck Institute for Biology of Ageing [Cologne]
3 Wellcome Trust Centre for Mitochondrial Research
4 IBGC - Institut de biochimie et génétique cellulaires
5 ZBMZ - Institute of Molecular Medicine and Cell Research
6 University of Cologne
7 Institute for Genetics and CECAD
8 CMMC - Center for Molecular Medicine [Cologne]
9 Vanderbilt University [Nashville]
10 Mitochondrial Research Group

Domaines: Sciences du Vivant [q-bio]

Christoph Freyer, Lynsey Cree, Arnaud Mourier, James Stewart, Camilla Koolmeister, et al.. Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission. Nature Genetics, 2012, 44 (11), pp.1282-1285. ⟨10.1038/ng.2427⟩. ⟨hal-02391255⟩