Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12

Frédéric Thuaud (1) , Yohann Bernard (1) , Gülen Türkeri (2) , Ronan Dirr (1) , Geneviève Aubert (3) , Thierry Cresteil (3) , Aurélie Baguet (4) , Catherine Tomasetto (4) , Yuri Svitkin , Nahum Sonenberg (5) , Canan G Nebigil (2) , Laurent Désaubry (1)

1 LIT - Laboratoire d'Innovation Thérapeutique
2 Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS)
3 ICSN - Institut de Chimie des Substances Naturelles
4 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
5 McGill University = Université McGill [Montréal, Canada]

Domaines: Cancer; Chimie organique

Frédéric Thuaud, Yohann Bernard, Gülen Türkeri, Ronan Dirr, Geneviève Aubert, et al.. Synthetic Analogue of Rocaglaol Displays a Potent and Selective Cytotoxicity in Cancer Cells: Involvement of Apoptosis Inducing Factor and Caspase-12. Journal of Medicinal Chemistry, 2009, 52 (16), pp.5176-5187. ⟨10.1021/jm900365v⟩. ⟨hal-02391094⟩