The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity

Hirokazu Kameyama , Kenji Uchimura (1) , Taro Yamashita , Kaori Kuwabara , Mineyuki Mizuguchi , Shang-Cheng Hung , Keiichiro Okuhira , Tomohiro Masuda , Tomoki Kosugi , Takashi Ohgita , Hiroyuki Saito , Yukio Ando , Kazuchika Nishitsuji

1 UGSF - Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576

Domaines: Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Biologie moléculaire; Médecine humaine et pathologie; Anatomie, Histologie, Anatomopathologie [q-bio.TO]

Hirokazu Kameyama, Kenji Uchimura, Taro Yamashita, Kaori Kuwabara, Mineyuki Mizuguchi, et al.. The Accumulation of Heparan Sulfate S-Domains in Kidney Transthyretin Deposits Accelerates Fibril Formation and Promotes Cytotoxicity. American Journal of Pathology, 2019, 189 (2), pp.308-319. ⟨10.1016/j.ajpath.2018.09.015⟩. ⟨hal-02382867⟩