Transcriptional and post-transcriptional regulation of c-mye expression during the differentiation of murine erythroleukemia Friend cells

Nadir Mechti (1) , Marc Piechaczyk (2) , J-M. Blanchard , L. Marty (3) , Anne Bonnieu (4) , Ph. Jeanteur , B. Lebleu (2)

1 IRIM - Institut de Recherche en Infectiologie de Montpellier
2 IGMM - Institut de Génétique Moléculaire de Montpellier
3 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
4 DCC - Unité de recherche différenciation cellulaire et croissance

c-myc RNA rapidly decreases to barely detectable levels in Friend erythroleukemia cells induced to differentiate upon the addition of dimethylsulfoxide. We show here that c-myc gene is down-regulated both at the transcriptional level presumably by a block in the elongation of primary transcripts and at the post-transcriptional level by an increase in the degradation of its mRNA.

Domaines: Sciences du Vivant [q-bio]

Nadir Mechti, Marc Piechaczyk, J-M. Blanchard, L. Marty, Anne Bonnieu, et al.. Transcriptional and post-transcriptional regulation of c-mye expression during the differentiation of murine erythroleukemia Friend cells. Nucleic Acids Research, 1986, 14 (24), pp.9653-9676. ⟨10.1093/nar/14.24.9653⟩. ⟨hal-02361132⟩