D Amino Acids Highlight the Catalytic Power of the Ribosome

Jean Lehmann (1, 2) , Shixin Ye

1 I2BC - Institut de Biologie Intégrative de la Cellule
2 SSFA - Séquence, Structure et Fonction des ARN

The possible mechanism(s) by which ribosomes make peptide bonds during protein synthesis have been explored for decades. Yet, there is no agreement on how the catalytic site, the peptidyl transferase center (PTC), promotes this reaction. Here, we discuss the results of recent investigations of translation with D amino acids that provide fresh insights into that longstanding question.

Mots clés: catalysis; D amino acids; induced fit; ribosome; translation

Domaines: Sciences du Vivant [q-bio]

Jean Lehmann, Shixin Ye. D Amino Acids Highlight the Catalytic Power of the Ribosome. Cell Chemical Biology, 2019, ⟨10.1016/j.chembiol.2019.10.007⟩. ⟨hal-02359949⟩