Gold nanoparticles induce cytotoxicity in the alveolar type-II cell lines A549 and NCIH441.

Chiara Uboldi (1) , Daniele Bonacchi (2) , Giada Lorenzi (2) , M Iris Iris Hermanns (1) , Christine Pohl (1) , Giovanni Baldi (2) , Ronald Unger (1) , Charles James Kirkpatrick (1)

1 JGU - Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University
2 CERICOL

Background: During the last years engineered nanoparticles (NPs) have been extensively used in different technologies and consequently many questions have arisen about the risk and the impact on human health following exposure to nanoparticles. Nevertheless, at present knowledge about the cytotoxicity induced by NPs is still largely incomplete. In this context, we have investigated the cytotoxicity induced by gold nanoparticles (AuNPs), which differed in size and purification grade (presence or absence of sodium citrate residues on the particle surface) in vitro, in the human alveolar type-II (ATII)-like cell lines A549 and NCIH441.

Domains: Life Sciences [q-bio]; Cellular Biology; Biotechnology; Toxicology; Material chemistry

Chiara Uboldi, Daniele Bonacchi, Giada Lorenzi, M Iris Iris Hermanns, Christine Pohl, et al.. Gold nanoparticles induce cytotoxicity in the alveolar type-II cell lines A549 and NCIH441.. Particle and Fibre Toxicology, 2009, 6 (1), pp.18. ⟨10.1186/1743-8977-6-18⟩. ⟨hal-02355011⟩