Embedment of Liposomes into Chitosan Physical Hydrogel for the Delayed Release of Antibiotics or Anaesthetics, and its First ESEM Characterization

S. Peers (1) , P. Alcouffe (1) , A. Montembault (1) , C. Ladavière (1)

1 IMP - Ingénierie des Matériaux Polymères

This work describes the characterization of an original liposomes/hydrogel assembly, and its application as a delayed-release system of antibiotics and anaesthetics. This system corresponds to drugloaded liposomes entrapped within a chitosan (CS) physical hydrogel. To this end, a suspension of pre-formed 1,2-dipalmitoyl-sn-glycero-3phosphocoline liposomes loaded with an antibiotic (rifampicin, RIF), an anaesthetic (lidocaine, LID), or a model fluorescent molecule (carboxyfluorescein, CF), was added to a CS solution. The CS gelation was subsequently carried out without any trace of chemical cross-linking agent or organic solvent in the final system. Liposomes within the resulting gelled CS matrix were characterized for the first time by environmental scanning electron microscopy. The release of drugs from the assembly was investigated by fluorescence or UV spectroscopy. The cumulative release profiles of RIF and LID (and also CF for comparison) were found to be lower from the "drug-in-liposomes-in-hydrogel" (DLH) assembly in comparison to "drug-in-hydrogel" (DH) system.

Mots clés: Chitosan; physical hydrogels; liposomes; drug delivery systems; rifampicin; lidocaine

Domaines: Chimie; Polymères; Matériaux

S. Peers, P. Alcouffe, A. Montembault, C. Ladavière. Embedment of Liposomes into Chitosan Physical Hydrogel for the Delayed Release of Antibiotics or Anaesthetics, and its First ESEM Characterization. Carbohydrate Polymers, 2019, pp.115532. ⟨10.1016/j.carbpol.2019.115532⟩. ⟨hal-02354077⟩