A chemically encoded timer for dual molecular delivery at tailored ranges and concentrations

Silvia Serra , Ahmed Alouane (1) , Thomas Le Saux (1) , Steve Huvelle (2) , Raphaël Plasson (3) , Frédéric Schmidt (4) , Ludovic Jullien (1) , Raphaël Labruère (5)

1 PASTEUR - Processus d'Activation Sélective par Transfert d'Energie Uni-électronique ou Radiatif (UMR 8640)
2 CBMCT - UMR 3666 / U1143 - Chimie biologique des membranes et ciblage thérapeutique
3 NORDITA - Nordic Institute for Theoretical Physics
4 CBMCT - UMR 3666 / U1143 - Chimie biologique des membranes et ciblage thérapeutique
5 ICMMO - Institut de Chimie Moléculaire et des Matériaux d'Orsay

Spatiotemporal control of molecular distribution is much in demand in many fields of chemistry. To address this goal, we exploit a low molecular weight branched self-immolative architecture, which acts as a triggerable chemically encoded timer for autonomous sequential release of two chemicals. Using a light-activated model liberating two distinct fluorophores, we generated a tunable spatially contrasted molecular distribution.

Mots clés: self-immolative spacers; energy propagation; cathepsin-b; release; kinetics; systems

Domaines: Chimie; Sciences du Vivant [q-bio]

Silvia Serra, Ahmed Alouane, Thomas Le Saux, Steve Huvelle, Raphaël Plasson, et al.. A chemically encoded timer for dual molecular delivery at tailored ranges and concentrations. Chemical Communications, 2018, 54 (49), pp.6396-6399. ⟨10.1039/c8cc03253j⟩. ⟨hal-02349382⟩