Self-generated theta oscillations in the hippocampus

Romain Goutagny (1) , Jesse Jackson , Sylvain Williams

1 LNCA - Laboratoire de neurosciences cognitives et adaptatives

Hippocampal theta rhythm is crucial for spatial memory and is thought to be generated by extrinsic inputs. In contrast, using a complete rat hippocampus in vitro, we found several intrinsic, atropine-resistant theta generators in CA1. These oscillators were organized along the septotemporal axis and arose independently from CA3. Our results suggest that CA1 theta rhythm can emerge from the coupling of multiple autonomous hippocampal theta oscillators.

Domaines: Biologie animale; Neurosciences [q-bio.NC]; Neurobiologie

Romain Goutagny, Jesse Jackson, Sylvain Williams. Self-generated theta oscillations in the hippocampus. Nature Neuroscience, 2009, 12 (12), pp.1491-1493. ⟨10.1038/nn.2440⟩. ⟨hal-02349366⟩