The development of brain magnetic resonance approaches in large animal models for preclinical research

Arsène Ella (1) , David A Barrière , Hans Adriaensen (1) , David Palmer (2) , Tracy R Melzer , Nadia L Mitchell , Matthieu Keller (1)

1 PRC - Physiologie de la reproduction et des comportements [Nouzilly]
2 LLNL - Lawrence Livermore National Laboratory

Magnetic resonance imaging is a very powerful ap-proach to perform anatomical and functional imaging explorations. Large animal models are perfectly suited for MRI studies using clinical devices and these tools are cur-rently being developed and improved. Here we highlight an example of MRI to demonstrate the efficacy of gene therapy in sheep models of Batten disease, a pediatric neurodegenerative disease.

Mots clés: brain; image analysis; magnetic resonance imaging; pathology

Domaines: Médecine vétérinaire et santé animale; Reproduction sexuée; Zoologie des vertébrés; Interactions entre organismes; Imagerie; Neurobiologie; Psychologie et comportements; Sciences cognitives; Science des productions animales; Zootechnie

Arsène Ella, David A Barrière, Hans Adriaensen, David Palmer, Tracy R Melzer, et al.. The development of brain magnetic resonance approaches in large animal models for preclinical research. Animal Frontiers, 2019, 9 (3), pp.44-51. ⟨10.1093/af/vfz024⟩. ⟨hal-02347381⟩