Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils

Charnese Bowes (1) , Michael Redd (2, 3) , Malika Yousfi (1) , Muriel Tauzin (1) , Emi Murayama (1) , Philippe Herbomel (1)

1 Macrophages et Développement de l’Immunité
2 Huntsman Cancer Institute [Salt Lake City]
3 UCL - University College of London [London]

Running title : actomyosin contractility maintains neutrophil nuclear integrity eTOC Bowes et al. show that in zebrafish embryos deficient in the cofilin cofactor AIP1/Wdr1, neutrophils display F-actin as cytoplasmic aggregates, spatially uncoupled from active myosin, then a progressive unwinding of their nucleus, followed by eruptive cell death. This adverse phenotype is fully rescued by depletion of another cofilin cofactor, coronin 1A.

Domaines: Sciences du Vivant [q-bio]; Biologie cellulaire; Biologie du développement

Charnese Bowes, Michael Redd, Malika Yousfi, Muriel Tauzin, Emi Murayama, et al.. Coronin 1A depletion restores the nuclear stability and viability of Aip1/Wdr1-deficient neutrophils. Journal of Cell Biology, 2019, 218 (10), pp.3258-3271. ⟨10.1083/jcb.201901024⟩. ⟨hal-02346164⟩