Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets

Mourad Bekhouche (1) , Cedric Leduc , Laura Dupont , Lauriane Janssen , Frédéric Delolme , Sandrine Vadon-Le Goff (2) , Nicolas Smargiasso (3) , Dominique Baiwir (4) , Gabriel Mazzucchelli (5) , Isabelle Zanella-Cléon (6) , Johanne Dubail (7) , Edwin de Pauw (8) , Betty Nusgens (9) , David Hulmes (2) , Catherine Moali (2) , Alain Colige (10)

1 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires
2 LBTI - Laboratoire de Biologie Tissulaire et d'ingénierie Thérapeutique UMR 5305
3 Université de Liège
4 Laboratory of Mass Spectrometry-GIGA-Proteomics
5 Laboratory of Mass Spectrometry, GIGA-R
6 IBCP - Institut de biologie et chimie des protéines [Lyon]
7 IMAGINE - U1163 - Imagine - Institut des maladies génétiques
8 Physical Chemistry and Mass Spectrometry Laboratory
9 CRCE - GIGA-Cancer
10 CHU-Liège - Centre Hospitalier Universitaire de Liège

Domaines: Génomique, Transcriptomique et Protéomique [q-bio.GN]; Interactions cellulaires [q-bio.CB]; Biologie cellulaire

Mourad Bekhouche, Cedric Leduc, Laura Dupont, Lauriane Janssen, Frédéric Delolme, et al.. Determination of the substrate repertoire of ADAMTS2, 3, and 14 significantly broadens their functions and identifies extracellular matrix organization and TGF-β signaling as primary targets. FASEB Journal, 2016, 30 (5), pp.1741-1756. ⟨10.1096/fj.15-279869⟩. ⟨hal-02342452⟩