Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors

Xue Zhi Zhao (1) , Steven M. Smith (2) , Daniel Maskell , Mathieu Métifiot (3) , Valerie E Pye (4) , Katherine Fesen , Christophe Marchand (5) , Yves Pommier (3) , Peter Cherepanov (6) , Stephen J. Hughes (7) , Terrence Burke

1 Department of Mathematics and Statistics
2 UTAS - University of Tasmania [Hobart, Australia]
3 Laboratory of Molecular Pharmacology
4 The Francis Crick Institute [London]
5 LBMCE - Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
6 Imperial College London
7 Nuffield Department of Surgery

Domaines: Virologie

Xue Zhi Zhao, Steven M. Smith, Daniel Maskell, Mathieu Métifiot, Valerie E Pye, et al.. Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. Journal of Medicinal Chemistry, 2017, 60 (17), pp.7315-7332. ⟨10.1021/acs.jmedchem.7b00596⟩. ⟨hal-02340319⟩