One-pot synthesis of a new generation of hybrid bisphosphonate polyoxometalate gold nanoparticles as antibiofilm agents

S. Tomane (1) , E. López-Maya (1) , S. Boujday (2) , V. Humblot (2) , J. Marrot (1) , N. Rabasso , J. Castells-Gil (3) , C. Sicard (1) , Anne Dolbecq (1) , P. Mialane (1) , A Vallée (1)

1 ILV - Institut Lavoisier de Versailles
2 LRS - Laboratoire de Réactivité de Surface
3 ICMol - Instituto de Ciencia Molecular

A reduced polyoxovanadate functionalized with bisphosphonate molecules was synthesized and used to prepare in one step hybrid organic-inorganic polyoxometalate decorated gold nanoparticles. These new composites were shown to strongly inhibit P. aeruginosa and S. epidermidis biofilms growth, the three components constituting the nanoparticles (Au 0 core, vanadium and alendronate) acting synergistically.

Domaines: Matériaux

S. Tomane, E. López-Maya, S. Boujday, V. Humblot, J. Marrot, et al.. One-pot synthesis of a new generation of hybrid bisphosphonate polyoxometalate gold nanoparticles as antibiofilm agents. Nanoscale Advances, 2019, 1 (9), pp.3400-3405. ⟨10.1039/c9na00401g⟩. ⟨hal-02335689⟩