Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells

Martina Bajzikova (1) , Jaromira Kovarova (1) , Ana Coelho (1, 2) , Stepana Boukalova (1) , Sehyun Oh , Katerina Rohlenova , David Svec (3) , Sona Hubackova , Berwini Endaya , Kristyna Judasova , Ayenachew Bezawork-Geleta , Katarina Kluckova , Laurent Chatre (4) , Renata Zobalova , Anna Novakova , Katerina Vanova , Zuzana Ezrova , Ghassan Maghzal , Silvia Magalhaes Novais , Marie Olsinova , Linda Krobova , Yong Jin An , Eliska Davidova , Zuzana Nahacka , Margarita Sobol , Teresa Cunha-Oliveira , Cristian Sandoval-Acuña , Hynek Strnad (5) , Tongchuan Zhang , Thanh Huynh , Teresa Serafim , Pavel Hozak (6) , Vilma Sardao , Werner J.H. Koopman (7) , Miria Ricchetti (4) , Paulo Oliveira , Frantisek Kolar , Mikael Kubista (8) , Jaroslav Truksa , Katerina Dvorakova-Hortova , Karel Pacak (9) , Robert Gurlich , Roland Stocker , Yaoqi Zhou (1) , Michael Berridge , Sunghyouk Park , Lanfeng Dong , Jakub Rohlena , Jiri Neuzil (1)

1 CAS - Czech Academy of Sciences [Prague]
2 UC - University of Coimbra [Portugal]
3 Laboratory of Gene Expression
4 Cellules Souches et Développement / Stem Cells and Development
5 Institute of Molecular Genetics ASCR
6 Laboratory of Biology of the Cell Nucleus
7 Department of Membrane Biochemistry
8 IBT / CAS - Institute of Biotechnology of the Czech Academy of Sciences
9 NICHD - Eunice Kennedy Shriver National Institute of Child Health and Human Development

Domaines: Sciences du Vivant [q-bio]; Cancer

Martina Bajzikova, Jaromira Kovarova, Ana Coelho, Stepana Boukalova, Sehyun Oh, et al.. Reactivation of Dihydroorotate Dehydrogenase-Driven Pyrimidine Biosynthesis Restores Tumor Growth of Respiration-Deficient Cancer Cells. Cell Metabolism, 2019, 29 (2), pp.399-416.e10. ⟨10.1016/j.cmet.2018.10.014⟩. ⟨hal-02324441⟩