Emerging Role of Eukaryote Ribosomes in Translational Control

Nicole Dalla Venezia (1) , Anne Vincent (1) , Virginie Marcel (1) , Frédéric Catez (1) , Jean-Jacques Diaz (1)

1 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon

Translation is one of the final steps that regulate gene expression. The ribosome is the effector of translation through to its role in mRNA decoding and protein synthesis. Many mechanisms have been extensively described accounting for translational regulation. However it emerged only recently that ribosomes themselves could contribute to this regulation. Indeed, though it is well-known that the translational efficiency of the cell is linked to ribosome abundance, studies recently demonstrated that the composition of the ribosome could alter translation of specific mRNAs. Evidences suggest that according to the status, environment, development, or pathological conditions, cells produce different populations of ribosomes which differ in their ribosomal protein and/or RNA composition. Those observations gave rise to the concept of "specialized ribosomes", which proposes that a unique ribosome composition determines the translational activity of this ribosome. The current review will present how technological advances have participated in the emergence of this concept, and to which extent the literature sustains this concept today.

Mots clés: rRNA modification; ribosome composition; specialized ribosome; ribosomal protein; translational regulation

Domaines: Sciences du Vivant [q-bio]; Biologie cellulaire; Organisation et fonctions cellulaires [q-bio.SC]

Nicole Dalla Venezia, Anne Vincent, Virginie Marcel, Frédéric Catez, Jean-Jacques Diaz. Emerging Role of Eukaryote Ribosomes in Translational Control. International Journal of Molecular Sciences, 2019, 20 (5), pp.1226. ⟨10.3390/ijms20051226⟩. ⟨hal-02324144⟩