Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α

Yan Dai (1) , Ruijie Liu , Anqun Chen , Leyi Gu , Shuchita Sharma , Weijing Cai , Fadi Salem , David J Salant , Jeffrey Pippin , Stuart Shankland , Marcus J Moeller , Norbert B Ghyselinck (2) , Xiaquiang Ding , Peter y Chuang , Kyung Lee , John Cijiang He

1 ICCF - Institut de Chimie de Clermont-Ferrand
2 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

Proliferation of glomerular epithelial cells, including the podocytes, is a key histologic feature of crescentic glomerulonephritis. We previously found that retinoic acid (RA) inhibits proliferation and induces differentiation of podocytes by activating RA receptor-α (RARα) in a murine model of HIV-associated nephropathy. Here, we examined whether RA would similarly protect podocytes

Domaines: Sciences du Vivant [q-bio]

Yan Dai, Ruijie Liu, Anqun Chen, Leyi Gu, Shuchita Sharma, et al.. Retinoic acid improves nephrotoxic serum–induced glomerulonephritis through activation of podocyte retinoic acid receptor α. Kidney International, 2017, 92 (6), pp.1444-1457. ⟨10.1016/j.kint.2017.04.026⟩. ⟨hal-02324133⟩