Signal Transduction: IMPlications for Ras-Dependent ERK Signaling

Stéphane Ory (1) , Deborah K Morrison

1 INCI - Institut des Neurosciences Cellulaires et Intégratives

Ras interacts with numerous downstream effectors to transmit a diverse array of cellular signals. A new study shows that a protein known as Impedes Mito-genic signal Propagation, IMP, is an E3 ubiquitin ligase that binds Ras and modulates MAP kinase sig-naling by regulating the scaffolding activity of KSR.

Domaines: Réseaux moléculaires [q-bio.MN]

Stéphane Ory, Deborah K Morrison. Signal Transduction: IMPlications for Ras-Dependent ERK Signaling. Current Biology - CB, 2004, 14 (7), pp.R277-R278. ⟨10.1016/j.cub.2004.03.023⟩. ⟨hal-02323550⟩