Synthesis of Aromatic Rings Embedded in Polycyclic Scaffolds by Triyne Cycloaddition: Competition between Carbonylative and Non-Carbonylative Pathways
Résumé
Cycloadditions have emerged as some of the most useful reactions for the formation of
polycyclic compounds. The carbonylative cycloaddition of triynes can lead to carbonylative and
non-carbonylative competitive pathways, each leading to the formation of an aromatic ring. We report
herein the one-pot synthesis of fully- and unsymmetrically-substituted tetracyclic 6,5,7,5-troponic
and 6,5,6,5-benzenoid scaffolds using pre-organized triynes showing the competition between these
two pathways.