Enantiomeric visualization using proton-decoupled natural abundance deuterium NMR in poly(γ-benzyl-l-glutamate) liquid crystalline solutions

Abstract : We report the first visualization of chiral molecules oriented in a polypeptide liquid crystalline system (PBLG) using proton-decoupled natural abundance deuterium NMR. The chiral discrimination is observed through measurements of the quadrupolar splitting differences and we demonstrate that the sensitivity of natural abundance deuterium NMR is sufficient to measure the differentiai ordering effects (DOEs) without the need for isotopie enrichment. The feasibility and the potential of this novel method were investigated using a 5.87 T spectrometer (proton frequency 250 MHz). Severa! examples of chiral discrimination are presented and particular emphasis is given to demonstrate the potential of this approach.
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https://hal.archives-ouvertes.fr/hal-02309102
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Submitted on : Wednesday, October 9, 2019 - 8:02:03 AM
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Philippe Lesot, Denis Merlet, Aharon Loewenstein, Jacques Courtieu. Enantiomeric visualization using proton-decoupled natural abundance deuterium NMR in poly(γ-benzyl-l-glutamate) liquid crystalline solutions. Tetrahedron: Asymmetry, Elsevier, 1998, 9 (11), pp.1871-1881. ⟨10.1016/S0957-4166(98)00179-7⟩. ⟨hal-02309102⟩

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