Ketenimines Generated from Ynamides: Versatile Building Blocks for Nitrogen-Containing Scaffolds

Robert H Dodd , Kevin Cariou (1)

1 ICSN - Institut de Chimie des Substances Naturelles

Using ynamides as readily available starting materials, a single step can generate highly reactive ketenimines which can then undergo a variety of transformations. The choice of the method for generating the ketenimine dictates the outcome of the reaction that can, moreover, be precisely steered through minor variations of the starting material. This Concept gives an overview of the different existing methodologies for this objective, showcasing the diverse nitrogen-containing frameworks that can be obtained by this highly versatile strategy.

Domaines: Chimie organique

Robert H Dodd, Kevin Cariou. Ketenimines Generated from Ynamides: Versatile Building Blocks for Nitrogen-Containing Scaffolds. Chemistry - A European Journal, 2018, 24 (10), pp.2297-2304. ⟨10.1002/chem.201704689⟩. ⟨hal-02307203⟩