Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki-Miyaura coupling

Timo Leermann , Pierre-Emmanuel Broutin , Frédéric Leroux (1) , Francoise Colobert-Leuenberger (1)

1 LIMA - Laboratoire d'innovation moléculaire et applications

An atropo-diastereoselective synthesis with diastereomeric ratio up to 98/2 towards the biaryl subunit of vancomycin based on the use of enantiopure β-hydroxysulfoxide derivs. as novel chiral auxiliary is reported.

Domaines: Chimie organique

Timo Leermann, Pierre-Emmanuel Broutin, Frédéric Leroux, Francoise Colobert-Leuenberger. Construction of the biaryl-part of vancomycin aglycon via atropo-diastereoselective Suzuki-Miyaura coupling. Organic & Biomolecular Chemistry, 2012, 10 (20), pp.4095-4102. ⟨10.1039/c2ob25373a⟩. ⟨hal-02306241⟩