Investigating the Putative Impact of Odors Purported to Have Beneficial Effects on Sleep: Neural and Perceptual Processes

Rochelle Ackerley (1) , Ilona Croy (2) , Håkan D Olausson (3) , Gaby Badre (4)

1 NSC - Neurosciences sensorielles et cognitives
2 TU Dresden - Technische Universität Dresden = Dresden University of Technology
3 Linköpings universitet
4 GU - Göteborgs Universitet = University of Gothenburg

Introduction Olfaction has an important role in physiological and affective processes, as well as the potential to have profound effects on activities such as sleep and learning. We investigated two commercially manufactured odors ("Deep Sleep" and "Oriental," from This Works) purported to promote sleep, compared with control odor, where we aimed to explore whether neural and behavioral differences existed after odor inhalation. Methods In a neuroimaging study, 30 healthy participants were exposed to the odors via an olfactometer during functional magnetic resonance imaging (fMRI). In a further behavioral study using 12 chronic insomniacs, we investigated whether the commercial odors showed effects on sleep during a double-blind, randomized home evaluation. Results In the neuroimaging, the odors were related to activation of olfactory-relevant areas, such as the orbitofrontal cortex, and we found positive connectivity between the piriform cortex and the hippocampus, amygdala, insula, and middle cingulate cortex. Deep Sleep specifically activated the superior temporal gyrus, whereas Oriental activated the caudate. Further, these commercial odors showed some beneficial impact on sleep. Conclusions The perceptual and neural impacts of the commercial odors showed that olfactory stimulation can potentially aid sleep and modify affective processes in a number of ways. Implications The present work opens up opportunities for further investigations into how different odors may lead to specific behavioral and physiological modifications, such as their impact on sleep and well-being, which may provide non-pharmacological alternative approaches.

Mots clés: Smell; Olfaction; Affect; Emotion; Well-being; Sleep

Domaines: Neurosciences; Psychologie

Rochelle Ackerley, Ilona Croy, Håkan D Olausson, Gaby Badre. Investigating the Putative Impact of Odors Purported to Have Beneficial Effects on Sleep: Neural and Perceptual Processes. Chemosensory Perception, In press, ⟨10.1007/s12078-019-09269-5⟩. ⟨hal-02304416⟩