Application of microfluidic chip with integrated optics for electrophoretic separations of proteins☆

Julien Vieillard (1) , R. Mazurczyk (1) , C.J. Morin (2) , B Hannes (1) , Y. Chevolot (1) , P. Desbène (1) , S Krawczyk (1)

1 LEOM - Laboratoire d'électronique, optoélectronique et microsystèmes
2 LASOC - LASOC

This paper describes the fabrication, the characterization and the applications of a capillary electrophoresis microchip. This hybrid device (glass/PDMS) features channels and optical waveguides integrated in one common substrate. It can be used for electrophoretic separation and fluorimetric detection of molecules. The microfluidic performance of the device is demonstrated by capillary zone and gel electrophoresis of proteins.

Mots clés: Lab-on-a-chip; Integrated optics; Microfluidic; Capillary electrophoresis

Domaines: Chimie organique; Chimie analytique; Catalyse; Chemo-informatique; Chimie thérapeutique; Chimie théorique et/ou physique

Julien Vieillard, R. Mazurczyk, C.J. Morin, B Hannes, Y. Chevolot, et al.. Application of microfluidic chip with integrated optics for electrophoretic separations of proteins☆. Journal of Chromatography B Biomedical Sciences and Applications, 2007, 845 (2), pp.218-225. ⟨10.1016/j.jchromb.2006.08.009⟩. ⟨hal-02281757⟩