Polypeptide Nanoparticles Obtained from Emulsion Polymerization of Amino Acid N-Carboxyanhydrides

Abstract : Polypeptide nanoparticles were obtained by the miniemulsion polymerization of S-(o-nitrobenzyl)-l-cysteine (NBC) N-carboxyanhydride (NCA). Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size. Subsequent UV-irradiation of the nanoparticle emulsions caused the in situ removal of the nitrobenzyl group and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the particles.
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https://hal.archives-ouvertes.fr/hal-02239076
Contributor : Olivier Sandre <>
Submitted on : Thursday, August 1, 2019 - 3:04:10 PM
Last modification on : Friday, August 2, 2019 - 2:25:37 AM

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Jaco Jacobs, Dražen Pavlović, Hannah Prydderch, Mohammad-Amin Moradi, Emmanuel Ibarboure, et al.. Polypeptide Nanoparticles Obtained from Emulsion Polymerization of Amino Acid N-Carboxyanhydrides. Journal of the American Chemical Society, American Chemical Society, In press, ⟨10.1021/jacs.9b06750⟩. ⟨hal-02239076⟩

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