Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA

Nicolas Duchemin (1, 2) , Erica Benedetti (3) , Lucas Bethge (4) , Stefan Vonhoff (4) , Sven Klussmann (4) , Jean-Jacques Vasseur (5) , Janine Cossy (2) , Michaël Smietana (5) , Stellios Arseniyadis (2)

1 ESPCI Paris - Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris
2 CBI - Chimie-Biologie-Innovation (UMR 8231)
3 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
4 Noxxon Pharma AG
5 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]

The recent development of biohybrid catalytic systems has allowed synthetic chemists to reach high levels of selectivity on a wide variety of valuable synthetic transformations. In this context, DNA-based catalysts have emerged as particularly appealing tools. Interestingly, while long RNA sequences (ribozymes) are known to catalyse specific biochemical reactions with remarkable efficiencies, RNA-based catalysts involving a catalytically active metal complex interacting in a non-covalent fashion with short sequences have never been evaluated to date. We report here our results, which have led to the first example involving a short RNA-based catalyst.

Mots clés: DNA; RIBOZYME; METALLOENZYMES; COMPLEX; RATE ACCELERATION; ACID CATALYSIS

Domaines: Catalyse; Chimie organique; Chimie thérapeutique

Nicolas Duchemin, Erica Benedetti, Lucas Bethge, Stefan Vonhoff, Sven Klussmann, et al.. Expanding biohybrid-mediated asymmetric catalysis into the realm of RNA. Chemical Communications, 2016, 52 (55), pp.8604-8607. ⟨10.1039/c6cc03540j⟩. ⟨hal-02197262⟩