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The cellular retinoic acid binding protein I is dispensable.

Abstract : The cellular retinoic acid binding proteins I and II (CRABPI and CRABPII) bind retinoic acid with high affinity, exhibit distinct patterns of expression during embryonic development, and are thought to play important roles in the RA signaling pathway. We have generated a targeted mutation of the CRABPI gene using the "hit-and-run" strategy and shown that it prevents the production of a functional CRABPI protein. Homozygous mutant mice were normal, indicating that CRABPI does not play a crucial role in the RA signaling pathway.
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https://hal.archives-ouvertes.fr/hal-02196238
Contributor : Philippe Gorry <>
Submitted on : Saturday, July 27, 2019 - 10:42:06 AM
Last modification on : Thursday, April 29, 2021 - 2:00:02 PM

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Philippe Gorry, T. Lufkin, A. Dierich, C. Rochette-Egly, D. Decimo, et al.. The cellular retinoic acid binding protein I is dispensable.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 1994, 91 (19), pp.9032-9036. ⟨10.1073/pnas.91.19.9032⟩. ⟨hal-02196238⟩

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