Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression

A. Kwiatkowska , M. Kijewska , M. Lipko , U. Hibner (1) , B. Kaminska

1 IGMM - Institut de Génétique Moléculaire de Montpellier

Mots clés: Genetic/drug effects; Actins/metabolism Animals Cell Line; Tumor Cell Movement/drug effects Cell Shape/drug effects Cyclosporine/pharmacology *Down-Regulation/drug effects Focal Adhesion Kinase 1/*metabolism Glioblastoma/*enzymology/pathology Humans Matrix Metalloproteinase 14/*metabolism Matrix Metalloproteinase 2/*metabolism Mice NF-kappa B/genetics Neoplasm Invasiveness Phosphatidylinositol 3-Kinases/antagonists & inhibitors/metabolism Phosphorylation/drug effects Protein Transport/drug effects Proto-Oncogene Proteins c-akt/antagonists & inhibitors/*metabolism Pseudopodia/drug effects/*enzymology Signal Transduction/drug effects Transcription

Domaines: Biochimie, Biologie Moléculaire

A. Kwiatkowska, M. Kijewska, M. Lipko, U. Hibner, B. Kaminska. Downregulation of Akt and FAK phosphorylation reduces invasion of glioblastoma cells by impairment of MT1-MMP shuttling to lamellipodia and downregulates MMPs expression. Biochimica et Biophysica Acta - Molecular Cell Research, 2011, 1813 (5), pp.655--67. ⟨10.1016/j.bbamcr.2011.01.020⟩. ⟨hal-02193320⟩