Epigenetics and the environment: emerging patterns and implications

Abstract : Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable chromatin modifications. There has been considerable interest in whether environmental factors modulate the establishment and maintenance of epigenetic modifications, and could thereby influence gene expression and phenotype. Chemical pollutants, dietary components, temperature changes and other external stresses can indeed have long-lasting effects on development, metabolism and health, sometimes even in subsequent generations. Although the underlying mechanisms remain largely unknown, particularly in humans, mechanistic insights are emerging from experimental model systems. These have implications for structuring future research and understanding disease and development.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-02193314
Contributor : Sarah Adele <>
Submitted on : Wednesday, July 24, 2019 - 1:59:39 PM
Last modification on : Thursday, July 25, 2019 - 1:22:29 AM

Identifiers

Collections

Citation

R. Feil, M. F. Fraga. Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet, 2011, 13 (2), pp.97--109. ⟨10.1038/nrg3142 nrg3142 [pii]⟩. ⟨hal-02193314⟩

Share

Metrics

Record views

18