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AB1144 ULTRA HIGH FIELD MRI MICROARCHITECTURE ANALYSIS IMPROVES THE PREDICTION OF PROXIMAL FEMUR FRACTURE: A COMBINED STUDY WITH EX VIVO BIOMECHANICAL TESTS

Abstract : The purpose of this study was to investigate bone microarchitecture of cadaveric proximal femurs using ultra-high field (UHF) 7-Tesla magnetic resonance imaging (MRI) and to compare the corresponding metrics with failure load assessed during mechanical compression test and areal bone mineral density (ABDM) measured using dual-energy X-ray absorptiometry. Materials and methods: ABDM of ten proximal femurs from five cadavers (5 women; mean age= 86.2 ± 3.8 (SD) years; range : 82.5-90 years) were investigated using dual-energy X-ray absorptiometry and the bone volume fraction, trabecular thickness, trabecular spacing, fractal dimension, Euler characteristics, Connectivity density and degree of anisotropy of each femur was quantified using UHF MRI. The whole set of specimens underwent mechanical compression tests to failure. Associations were searched using correlation tests and multiple regression analysis.
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https://hal.archives-ouvertes.fr/hal-02186975
Contributor : Jean-Christophe Souplet <>
Submitted on : Thursday, July 18, 2019 - 5:37:29 PM
Last modification on : Wednesday, August 19, 2020 - 12:08:22 PM

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Daphne Guenoun, Martine Pithioux, Jean-Christophe Souplet, Sandrine Guis, Thomas Le Corroller, et al.. AB1144 ULTRA HIGH FIELD MRI MICROARCHITECTURE ANALYSIS IMPROVES THE PREDICTION OF PROXIMAL FEMUR FRACTURE: A COMBINED STUDY WITH EX VIVO BIOMECHANICAL TESTS. Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019, Jun 2019, Madrid, Spain. pp.2033.3-2034. ⟨hal-02186975⟩

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