Modular Access to N-Substituted cis -3,5-Diaminopiperidines

Aurélie Blond (1) , Paul Dockerty , Raquel Alvarez (2) , Serge Turcaud (1) , Thomas Lecourt (3) , Laurent Micouin (4)

1 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
2 Instituto Nacional de Estadística. Madrid.
3 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
4 SSMIP - Synthèse et structure de molécules d'interet pharmacologique

A sequence of oxidative cleavage/reductive amination/hydrogenolysis enables the preparation of N-substituted cis-3,5-diaminopiperidines from a readily available bicyclic hydrazine. This new synthetic route provides a simple and general access to RNA-friendly fragments with a good chemical diversity.

Domaines: Chimie organique

Aurélie Blond, Paul Dockerty, Raquel Alvarez, Serge Turcaud, Thomas Lecourt, et al.. Modular Access to N-Substituted cis -3,5-Diaminopiperidines. Journal of Organic Chemistry, 2013, 78 (23), pp.12236-12242. ⟨10.1021/jo401994y⟩. ⟨hal-02186757⟩