Direct Synthesis of 1,4-Disubstituted-5-alumino-1,2,3-triazoles: Copper-Catalyzed Cycloaddition of Organic Azides and Mixed Aluminum Acetylides

Yuhan Zhou (1) , Thomas Lecourt (1) , Laurent Micouin (1)

1 SSMIP - Synthèse et structure de molécules d'interet pharmacologique

Aluminotriazoles are obtained in a fully chemo‐ and regioselective manner by a copper‐catalyzed cycloaddition of organic azides with mixed‐aluminum acetylides (see scheme). The carbon-aluminum bond, which is unaffected by the first transformation, is still able to react further with different electrophiles.

Domaines: Chimie organique; Chimie thérapeutique

Yuhan Zhou, Thomas Lecourt, Laurent Micouin. Direct Synthesis of 1,4-Disubstituted-5-alumino-1,2,3-triazoles: Copper-Catalyzed Cycloaddition of Organic Azides and Mixed Aluminum Acetylides. Angewandte Chemie International Edition, 2010, 49 (14), pp.2607-2610. ⟨10.1002/anie.200907016⟩. ⟨hal-02185392⟩