Skip to Main content Skip to Navigation
Journal articles

Bi-layered silane-TiO2/collagen coating to control biodegradation and biointegration of Mg alloys

Abstract : Magnesium alloys have shown high potential as biodegradable implants for bone repair applications. However, their fast degradation in physiological media demands tuning their corrosion rate to accompany the natural tissue healing processes. Here, a new bi-layered silane-TiO2/collagen coating efficient in stabilizing and biofunctionalizing the surface of AZ31 and ZE41 Mg alloys is presented. Corrosion tests performed in cell culture medium over 7 weeks showed that the bi-layered coating promotes the formation of a stable layer of Mg(OH)2/MgCO3/CaCO3 that provides effective protection to the alloys at advanced immersion stages. The intrinsic reactivity of each alloy plus formation of transitory calcium phosphate phases, resulted in distinct corrosion behavior in the short term. Cell experiments showed that the bi-layered coating improved osteoblasts and fibroblasts proliferation compared to bare and silane-TiO2-coated alloys. Different responses in terms of cell adhesion could be related to the intrinsic corrosion rate of each alloy and some toxicity from the alloying elements. The results evidenced the complex interplay between alloy nature, coating-alloy combination and cell type. The silane-TiO2/collagen coating showed to be a promising strategy to improve cell response and viability and to control degradation rate of Mg alloys in the long term.
Document type :
Journal articles
Complete list of metadatas

Cited literature [53 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-02171960
Contributor : Thibaud Coradin <>
Submitted on : Wednesday, July 17, 2019 - 4:04:03 PM
Last modification on : Wednesday, September 11, 2019 - 3:18:03 PM

File

Bi-layered silane-TiO2collagen...
Files produced by the author(s)

Identifiers

Citation

Laura Córdoba, Christophe Hélary, Fatima Montemor, Thibaud Coradin. Bi-layered silane-TiO2/collagen coating to control biodegradation and biointegration of Mg alloys. Materials Science and Engineering: C, Elsevier, 2019, 94, pp.126-138. ⟨10.1016/j.msec.2018.09.032⟩. ⟨hal-02171960⟩

Share

Metrics

Record views

54

Files downloads

137