Structural Rearrangements in the C-Terminal Domain Homolog of Orange Carotenoid Protein are Crucial for Carotenoid Transfer

Dvir Harris (1) , Adjele Wilson (2, 3, 4, 5) , Fernando Muzzopappa (3, 4, 5) , Nikolai N. Sluchanko , Thomas Friedrich (6) , Eugene G. Maksimov , Diana Kirilovsky (3, 4, 5) , Noam Adir (1)

1 Faculty of Chemistry
2 IBITECS - Institut de Biologie et de Technologies de Saclay
3 I2BC - Institut de Biologie Intégrative de la Cellule
4 MROP - Mécanismes régulateurs chez les organismes photosynthétiques
5 B3S - Département Biochimie, Biophysique et Biologie Structurale
6 HUB - Institut für Reine Mathematik

Dvir Harris et al. present the structure of a homolog of the orange carotenoid protein (OCP) C-terminal domain, elaborating on this protein family’s carotenoid transfer mechanism. They observed major structural shifts in the homolog compared to that of the OCP C-terminal domain, with a strong positive impact on carotenoid uptake and delivery.

Domaines: Sciences du Vivant [q-bio]

Dvir Harris, Adjele Wilson, Fernando Muzzopappa, Nikolai N. Sluchanko, Thomas Friedrich, et al.. Structural Rearrangements in the C-Terminal Domain Homolog of Orange Carotenoid Protein are Crucial for Carotenoid Transfer. Biophysical Journal, 2019, 116 (3), pp.47A--47A. ⟨10.1016/j.bpj.2018.11.300⟩. ⟨hal-02171149⟩