A temporary compendium of thyroid hormone target genes in brain

Fabrice Chatonnet (1) , Frederic Flamant (1) , Beatriz Morte (2)

1 IGFL - Institut de Génomique Fonctionnelle de Lyon
2 Instituto de Investigaciones Biomédicas, Center for Biomedical Research on Rare Diseases (Ciberer), Instituto de Salud Carlos III, Madrid, Spain

Thyroid hormone controls a number of developmental and physiological processes in the brain by directly acting on gene expression. Transcriptome analyses in rodent identified a number of thyroid hormone regulated genes in several brain areas at different stages. Genome wide analysis of chromatin occupancy in a neural cell line also identified a subset of genes which transcription is likely to be directly regulated by thyroid hormone receptors in neurons. However, the abundance of these data and apparent discrepancies between studies brought some confusion.

Mots clés: Cistrome; Nuclear receptors; Thyroid hormone; Transcriptome

Domaines: Sciences du Vivant [q-bio]

Fabrice Chatonnet, Frederic Flamant, Beatriz Morte. A temporary compendium of thyroid hormone target genes in brain. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2015, 1849 (2), pp.122-129. ⟨10.1016/j.bbagrm.2014.05.023⟩. ⟨hal-02164764⟩