Synthesis of peptide di-aldehyde precursor for stepwise chemoselective ligations via oxime bonds

Abstract : To synthezise a triple-function branched peptide in a modular way, we present a new strategy based on orthogonal generation of two aldehyde functions from an acetal and a 2-amino alcohol. Successive unmaskings of aldehyde functions of the stem peptide affords stepwise chemoselective ligations of two (aminooxy)acetyl peptides via oxime bonds.
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Dominique Lelièvre, Corinne Bure, Fabrice Laot, Agnès F. Delmas. Synthesis of peptide di-aldehyde precursor for stepwise chemoselective ligations via oxime bonds. Tetrahedron Letters, Elsevier, 2001, 42 (2), pp.235-238. ⟨10.1016/S0040-4039(00)01907-9⟩. ⟨hal-02146709⟩

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